High-resolution image-based simulation reveals membrane strain concentration on osteocyte processes caused by tethering elements

High-resolution image-based simulation reveals membrane strain concentration on osteocyte processes caused by tethering elements

Osteocytes are vital for regulating bone remodeling by sensing the flow-induced mechanical stimuli applied to their cell processes. In this mechanosensing mechanism, tethering elements (TEs) connecting the osteocyte process with the canalicular wall potentially amplify the strain on the osteocyte pr...

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Bibliographic Details
Main Authors: Adachi, T. (Author), Kameo, Y. (Author), Kamioka, H. (Author), Yokoyama, Y. (Author)
Format: Article
Language:English
Published: Springer Science and Business Media Deutschland GmbH 2021
Subjects:
article
biological model
biomechanics
Bone
Canaliculus
cell membrane
Cell Membrane
Computational biomechanics
computer simulation
Computer Simulation
controlled study
electron microscopy
flow kinetics
High resolution image
High-resolution imaging
human cell
Image processing
Image-based simulation
Imaging, Three-Dimensional
Interaction simulations
Irregular shape
Mechanical stimulus
mechanical stress
Mechanosensing
Membrane strain
Microstructure
Models, Biological
Nano-meter scale
osteocyte
Osteocyte
Osteocytes
pathology
Rheology
simulation
Stress, Mechanical
tension
Tethering element
three-dimensional imaging
tomography
Ultra high voltage
ultrastructure
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