Modeling stem cell nucleus mechanics using confocal microscopy

Modeling stem cell nucleus mechanics using confocal microscopy

Nuclear mechanics is emerging as a key component of stem cell function and differentiation. While changes in nuclear structure can be visually imaged with confocal microscopy, mechanical characterization of the nucleus and its sub-cellular components require specialized testing equipment. A computat...

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Bibliographic Details
Main Authors: Fitzpatrick, C.K (Author), Goelzer, M. (Author), Judex, S. (Author), Kennedy, Z. (Author), Newberg, J. (Author), Uzer, G. (Author)
Format: Article
Language:English
Published: Springer Science and Business Media Deutschland GmbH 2021
Subjects:
animal
Animals
Article
atomic force microscopy
Atomic force microscopy
biological model
C57BL mouse
Cell culture
cell isolation
cell nucleus
Cell Nucleus
chromatin
Chromatin
chromatin structure
Chromosomes
Computational framework
Computational model
computer model
confocal microscopy
Confocal microscopy
controlled study
Conversion factor
cytology
elasticity
Elasticity
finite element analysis
Finite element analysis
Finite element method
human
human cell
lamin A
Lamin A/C
lamin C
Lamin Type A
male
Male
Mechanical characterizations
Mechanobiology
mesenchymal stem cell
Mesenchymal stem cell
Mesenchymal stem cells
metabolism
Mice, Inbred C57BL
Microscopy, Atomic Force
Microscopy, Confocal
Models, Biological
Nuclear structure
Nucleus
response surface method
RNA, Small Interfering
root mean squared error
sensitivity analysis
small interfering RNA
stem cell
Stem cells
Stem Cells
Stiffness
Testing equipment
Voxel intensities
Young modulus
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