Thymoquinone prevents β-amyloid neurotoxicity in primary cultured cerebellar granule neurons

Thymoquinone prevents β-amyloid neurotoxicity in primary cultured cerebellar granule neurons

Thymoquinone (TQ), a bioactive constituent of Nigella sativa Linn (N. sativa) has demonstrated several neuropharmacological attributes. In the present study, the neuroprotective properties of TQ were investigated by studying its anti-apoptotic potential to diminish β-amyloid peptide 1-40 sequence (A...

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Bibliographic Details
Main Authors: Azmi, N.H (Author), Chan, K.W (Author), Ghafar, S.A.A (Author), Imam, M.U (Author), Iqbal, S. (Author), Ismail, M. (Author), Ismail, N. (Author), Latiff, L.A (Author), Mazlan, M. (Author)
Format: Article
Language:English
Published: Springer Science and Business Media, LLC 2013
Subjects:
Alzheimer's disease
amino acid analysis
amino acid sequence
amyloid beta protein
Amyloid beta-Peptides
animal cell
animal experiment
animal tissue
Animals
Apoptosis
article
Benzoquinones
brain cell
caspase 3
caspase 8
caspase 9
Caspases
cell structure
Cells, Cultured
cerebellar granule nerve cell
Cerebellum
Chromatin
chromatin condensation
controlled study
DNA
Electron Spin Resonance Spectroscopy
enzyme activation
Enzyme Activation
nerve cell necrosis
nerve cell network
Neurites
Neurons
neuroprotection
Neuroprotective Agents
neurotoxicity
Neurotoxicity
Neurotoxins
newborn
Nigella sativa
nonhuman
Primary cultured cerebellar granule neurons
priority journal
rat
Rats
Rats, Sprague-Dawley
reactive oxygen metabolite
signal transduction
thymoquinone
Thymoquinone
β-Amyloid
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