Assessing the influence of neglected GC-FID variables on the multiple responses using multivariate optimization for the determination of ethanol and acetonitrile in radiopharmaceuticals

Assessing the influence of neglected GC-FID variables on the multiple responses using multivariate optimization for the determination of ethanol and acetonitrile in radiopharmaceuticals

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Analytical gas chromatography in line with a flame ionization detector (GC-FID) method was developed and validated for direct determination of organic solvents in [18F]fluoro-ethyl-tyrosine ([18F]FET), [18F]fluoromisonidazole ([18F]FMISO) and [18F]fluorothymidine ([18F]FLT). Variables of the splitle...

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Bibliographic Details
Main Authors: Abdul Razak, H.R (Author), Ahmad Saad, F.F (Author), Hassan, H. (Author), Othman, M.F (Author), Zakaria, Z.A (Author)
Format: Article
Language:English
Published: Springer Nature 2021
Series:SN Applied Sciences
Subjects:
Acetonitrile
Amino acids
Desirability function
Direct determination
Ethanol
Flame ionization detectors
Full factorial design
Gas chromatography
Gas chromatography-flame ionization detection (GC-FID)
Gas generators
Injection temperature
Ionization of gases
Multivariate optimization
Organic solvent analysis
Quality control
Quantitative determinations
Radiopharmaceutical
Splitless time
Technical requirement
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