Assessing the influence of neglected GC-FID variables on the multiple responses using multivariate optimization for the determination of ethanol and acetonitrile in radiopharmaceuticals

Analytical gas chromatography in line with a flame ionization detector (GC-FID) method was developed and validated for direct determination of organic solvents in [18F]fluoro-ethyl-tyrosine ([18F]FET), [18F]fluoromisonidazole ([18F]FMISO) and [18F]fluorothymidine ([18F]FLT). Variables of the splitle...

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Bibliographic Details
Main Authors:	Abdul Razak, H.R (Author), Ahmad Saad, F.F (Author), Hassan, H. (Author), Othman, M.F (Author), Zakaria, Z.A (Author)
Format:	Article
Language:	English
Published:	Springer Nature 2021
Series:	SN Applied Sciences
Subjects:	Acetonitrile Amino acids Desirability function Direct determination Ethanol Flame ionization detectors Full factorial design Gas chromatography Gas chromatography-flame ionization detection (GC-FID) Gas generators Injection temperature Ionization of gases Multivariate optimization Organic solvent analysis Quality control Quantitative determinations Radiopharmaceutical Splitless time Technical requirement
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Assessing the influence of neglected GC-FID variables on the multiple responses using multivariate optimization for the determination of ethanol and acetonitrile in radiopharmaceut...

by Abdul Razak, HR, Ahmad Saad, FF, Hassan, H, Othman, MF, Zakaria, ZA
Published 2021

View Fulltext in Publisher

Article

Assessing the influence of neglected GC-FID variables on the multiple responses using multivariate optimization for the determination of ethanol and acetonitrile in radiopharmaceuticals

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