Highly sensitive detection of EGFR L858R mutation at the mRNA level

Highly sensitive detection of EGFR L858R mutation at the mRNA level

The missense mutation EGFR L858R implies increased sensitivity to EGFR tyrosine kinase inhibitor (TKIs) therapy, despite a significant non-response rate. Currently, detection of EGFR L858R mutation is mostly DNA based, therefore, the allele-specific expression level of the mutated gene and its clini...

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Bibliographic Details
Main Authors: Nguyen, B. (Author), Nguyen, H. (Author), Nguyen, L. (Author), Nguyen, U. (Author), Pham, M. (Author), Pham, Q. (Author), Stenman, J. (Author), Tho, H. (Author), Vu, T. (Author)
Format: Article
Language:English
Published: Academic Press Inc. 2022
Subjects:
Allele-specific gene expression
Amino acids
Biomarkers
Cancer biomarker
Cancer biomarkers
Circulating mRNA
EGFR l858r mutation
EGFR L858R mutation
Genes expression
Liquid biopsy
mRNA levels
Mutation analysis
PCR assay
Polymerase chain reaction
RNA
RNA-based mutation analyse
RNA-based mutation analysis
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