Efficient hepatoprotective activity of cranberry extract against CCl4-induced hepatotoxicity in Wistar albino rat model: Down-regulation of liver enzymes and strong antioxidant activity

Efficient hepatoprotective activity of cranberry extract against CCl4-induced hepatotoxicity in Wistar albino rat model: Down-regulation of liver enzymes and strong antioxidant activity

Objective To investigate the hepatoprotective efficacy of cranberry extract (CBE) against carbon tetrachloride (CCl4)-induced hepatic injury using in-vivo animal model. Methods The hepatoprotective efficacy of CBE (200 and 400 mg/kg) was investigated against CCl4 (4 mL/kg)-induced hepatotoxicity, el...

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Bibliographic Details
Main Authors: Ayyaz, U. (Author), Hussain, F. (Author), Hussain, Z. (Author), Malik, A. (Author), Rana, Z. (Author), Shafique, H. (Author)
Format: Article
Language:English
Published: Elsevier (Singapore) Pte Ltd 2017
Subjects:
alanine aminotransferase
alanine aminotransferase blood level
alkaline phosphatase
alkaline phosphatase blood level
animal experiment
animal model
antioxidant activity
Article
aspartate aminotransferase
aspartate aminotransferase blood level
carbon tetrachloride
Carbon tetrachloride
catalase
clavazin
controlled study
cranberry extract
Cranberry extract
dose response
down regulation
drug effect
glutathione
Hepatoprotective
Hepatotoxicity
in vivo study
Liver enzymes
liver injury
liver protection
liver protective agent
liver toxicity
male
malonaldehyde
nonhuman
Oxidative stress
priority journal
protein
protein blood level
rat
spectrophotometry
superoxide dismutase
unclassified drug
Wistar rat
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