Screening methylation of DNA repair genes in the oral mucosa of chronic smokers

Screening methylation of DNA repair genes in the oral mucosa of chronic smokers

Objective: The aim of this study was to evaluate the epigenetic changes in the process of oral carcinogenesis by screening the methylation of repair genes in chronic smokers. Design: Two groups were formed: Group 1: 16 smokers with consumption of 20 cigarettes/day for at least 10 years; and Group 2:...

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Bibliographic Details
Main Authors: Almeida, J.D (Author), Campos, M.S (Author), Carta, C.F.L (Author), de Barros, P.P (Author), Jorge, A.O.C (Author), Nunes, F.D (Author), Oliveira Alves, M.G (Author), Scholz, J. (Author)
Format: Article
Language:English
Published: Elsevier Ltd 2018
Subjects:
adult
Adult
Carcinogenesis
case control study
Case-Control Studies
DNA methylation
DNA Methylation
DNA repair
DNA Repair
DNA repair protein XRCC1
double strand break repair protein MRE11
epigenetics
Epigenomics
genetics
human
Humans
male
Male
metabolism
Methylation
Mismatch Repair Endonuclease PMS2
mismatch repair protein PMS2
MLH3 protein, human
mouth mucosa
Mouth Mucosa
Mouth Neoplasms
mouth tumor
MRE11 Homologue Protein
MRE11A protein, human
MutL Proteins
Oral mucosa
PMS2 protein, human
protein MutL
real time polymerase chain reaction
Real-Time Polymerase Chain Reaction
Repair gene
Smokers
smoking
Smoking
X-ray Repair Cross Complementing Protein 1
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