Direct evidence for the age-dependent demise of GNAS-mutated cells in oral fibrous dysplasia

Direct evidence for the age-dependent demise of GNAS-mutated cells in oral fibrous dysplasia

Objective: Fibrous dysplasia (FD) is a benign bone disease characterized by fibro-osseous lesions. FD is caused by somatic mutations in the gene, guanine nucleotide-binding protein, alpha stimulating activity polypeptide 1 (GNAS), which encodes the G protein subunit, Gsα. FD manifests early in life,...

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Bibliographic Details
Main Authors: Bessho, K. (Author), Haga, H. (Author), Ikeno, M. (Author), Isobe, Y. (Author), Kiso, H. (Author), Koyama, N. (Author), Nakao, K. (Author), Shimizu, A. (Author), Sugai, M. (Author), Takahashi, K. (Author)
Format: Article
Language:English
Published: Elsevier Ltd 2018
Subjects:
adult
Adult
age
Age Factors
chromogranin
Chromogranins
diagnostic imaging
dna mutational analysis
DNA Mutational Analysis
DNA sequencing
female
Female
fibrous dysplasia
Fibrous dysplasia
Fibrous Dysplasia of Bone
genetics
GNAS protein, human
GTP-Binding Protein alpha Subunits, Gs
human
Humans
immunohistochemistry
Immunohistochemistry
jaw disease
male
Male
Mandibular Diseases
Maxillofacial region
panoramic radiography
Radiography, Panoramic
reoperation
Reoperation
stimulatory guanine nucleotide binding protein
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