Deletion of the T-box transcription factor gene, Tbx1, in mice induces differential expression of genes associated with cleft palate in humans

Deletion of the T-box transcription factor gene, Tbx1, in mice induces differential expression of genes associated with cleft palate in humans

Objective: We examined the function of the T-box transcription factor 1 (TBX1) in palatogenesis. Design: Tbx1-knockout mice were histologically examined by hematoxylin and eosin staining. Next, secondary palatal shelves dissected from wild type or Tbx1-knockout mice embryos at embryonic day 13.5 wer...

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Bibliographic Details
Main Authors: Funato, N. (Author), Yanagisawa, H. (Author)
Format: Article
Language:English
Published: Elsevier Ltd 2018
Subjects:
4 aminobutyric acid A receptor
animal
Animals
Animals, Newborn
Bifid uvula
cleft palate
Cleft palate
Cleft Palate
Cytoskeletal Proteins
cytoskeleton protein
DiGeorge syndrome
embryology
Gabrb3 protein, mouse
gene deletion
Gene Deletion
gene expression
Gene Expression
genetics
human
Humans
knockout mouse
Mice
Mice, Knockout
microarray analysis
Microarray Analysis
mouse
muscle protein
Muscle Proteins
nebulin
newborn
palate
Palate
phenotype
Phenotype
real time polymerase chain reaction
Real-Time Polymerase Chain Reaction
Receptors, GABA-A
Soft palate
T box transcription factor
T-Box Domain Proteins
Tbx1
Tbx1 protein, mouse
Velocardiofacial syndrome
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