Prenatal administration of multipotent adult progenitor cells modulates the systemic and cerebral immune response in an ovine model of chorioamnionitis

Prenatal administration of multipotent adult progenitor cells modulates the systemic and cerebral immune response in an ovine model of chorioamnionitis

Systemic and cerebral inflammation following antenatal infection (e.g. chorioamnionitis) and dysregulation of the blood brain barrier (BBB) are major risk factors for abnormal neonatal brain development. Administration of multipotent adult progenitor cells (MAPCs) represents an interesting pharmacol...

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Bibliographic Details
Main Authors: Damoiseaux, M. (Author), Klein, L. (Author), Ophelders, D.R.M.G (Author), Reutelingsperger, C.P.M (Author), Rutten, B.P.F (Author), Schurgers, L.J (Author), van den Hove, D. (Author), Wolfs, T.G.A.M (Author)
Format: Article
Language:English
Published: Elsevier Inc. 2022
Subjects:
adult
animal cell
animal experiment
animal model
animal tissue
Antenatal inflammation
Article
autopsy
blood brain barrier
brain blood vessel
brain protection
chorioamnionitis
choroid plexus
controlled study
endothelium
female
fetus
fetus brain
gestational age
host resistance
human
human cell
immune response
immunocompetent cell
immunohistochemistry
immunomodulation
Immunomodulation
in utero stem cell transplantation
interleukin 6
intra-amniotic drug administration
intravenous drug administration
lipocortin 1
lipopolysaccharide
lymphocyte percentage
macrophage
multipotent stem cell
myeloperoxidase
Neuro-immune axis
neuroimmunology
neutrophil count
nonhuman
ovine model
preclinical study
prenatal period
protein blood level
protein expression
protein expression level
receptor type tyrosine protein phosphatase C
sodium chloride
Stem cell therapy
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