Cryo-EM structures of the β3 adrenergic receptor bound to solabegron and isoproterenol
The β3-adrenergic receptor (β3AR) is the most essential drug target for overactive bladder and has therapeutic potentials for the treatments of type 2 diabetes and obesity. Here, we report the cryo-electron microscopy structures of the β3AR-Gs signaling complexes with the selective agonist, solabegr...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier B.V.
2022
|
Subjects: | |
Online Access: | View Fulltext in Publisher |