Targeting ERK3/MK5 complex for treatment of obesity and diabetes

Targeting ERK3/MK5 complex for treatment of obesity and diabetes

Kinases represent one of the largest druggable families of proteins. Importantly, many kinases are aberrantly activated/de-activated in multiple organs during obesity, which contributes to the development of diabetes and associated diseases. Previous results indicate that the complex between Extrace...

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Bibliographic Details
Main Authors: Demczuk, A. (Author), El-Merahbi, R. (Author), Karwen, T. (Author), Kassouf, T. (Author), Löffler, M.C (Author), Loza-Valdes, A. (Author), Marcos, M. (Author), Noh, M. (Author), Reuter, S. (Author), Romero-Becerra, R. (Author), Sabio, G. (Author), Sumara, G. (Author), Torres, J.L (Author), Viera, J.T (Author), Wojda, U. (Author)
Format: Article
Language:English
Published: Elsevier B.V. 2022
Subjects:
adipocytes
cellular respiration
diabetes
ERK3 (MAPK6)
GLPG0259
lipolysis
MAPK-activated protein kinase 5 (MK5)
obesity
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