Extravascular rapamycin film inhibits the endothelial-to-mesenchymal transition through the autophagy pathway to prevent vein graft restenosis

Extravascular rapamycin film inhibits the endothelial-to-mesenchymal transition through the autophagy pathway to prevent vein graft restenosis

Following vein grafting, the vein must adapt to arterial hemodynamics, which can lead to intimal hyperplasia (IH) and restenosis. Moreover, endothelial-to-mesenchymal transition (EndMT) components are highly associated with IH. Therefore, in this study, we aimed to design an extravascular film loade...

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Bibliographic Details
Main Authors: Chu, T. (Author), Dai, C. (Author), Gao, L. (Author), Ge, J. (Author), Li, X. (Author), Yin, H. (Author)
Format: Article
Language:English
Published: Elsevier Ltd 2022
Subjects:
Arterial haemodynamics
Autophagy
Biocompatibility
Cell death
Diseases
Endothelial-to-mesenchymal transition
Film
Grafting (chemical)
Intimal hyperplasia
In-vivo
Physicochemical properties
Rapamycin
Restenosis
Stenoses
Transition components
Vein grafts
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