Novel electrochemical biosensors for investigating the interactions between atezolizumab and PD-1/PD-L1 and screening their small-molecular inhibitors

Novel electrochemical biosensors for investigating the interactions between atezolizumab and PD-1/PD-L1 and screening their small-molecular inhibitors

PD-1/PD-L1 pathway plays an important role in tumor immunotherapy. A novel immobilized overexpression cell electrochemical sensor was constructed using N-doped graphene-chitosan-Pt nanoparticles (NGR–CS–PtNPs) and polyaniline (PANI) to investigate the interaction between atezolizumab and HEK293 cell...

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Bibliographic Details
Main Authors: Hu, X. (Author), Huang, T. (Author), Kehriman, N. (Author), Kuang, W. (Author), Li, C. (Author), Ling, X. (Author), Yan, Y. (Author), Zhang, X. (Author), Zou, J. (Author)
Format: Article
Language:English
Published: Elsevier Ltd 2022
Subjects:
Binding constant
Biosensors
Cell/B.E
Cell/BE
Cell-be
Cells
Cytology
Diagnosis
Doping (additives)
Drug delivery
Drug screening
Drug-screening
Electrochemical biosensor
Electrochemical sensors
Gold nanoparticles
HEK293 cells
Immune checkpoint inhibitor
Molecules
PD-1/PD-l1 interaction
PD-1/PD-L1 interaction
Proteins
Small molecule inhibitor
Small-molecule inhibitors
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