Possible mechanisms of antinociception of methanol extract of Melastoma malabathricum leaves

Possible mechanisms of antinociception of methanol extract of Melastoma malabathricum leaves

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Melastoma malabathricum L., Melastomaceae, has been traditionally used to relieve diverse pain-related ailments. The objectives of the present study were to determine the antinociceptive activity of methanol extract of M. malabathricum leaves and to elucidate the possible mechanisms of antinocicepti...

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Bibliographic Details
Main Authors: Ching, S.M (Author), Desa, M.N.M (Author), Jaios, E.S (Author), Kadir, A.A (Author), Rahman, S. (Author), Zakaria, Z.A (Author)
Format: Article
Language:English
Published: Sociedade Brasileira de Farmacognosia 2016
Subjects:
acetic acid
acetylsalicylic acid
animal experiment
animal model
antinociception
arginine
Article
capsaicin
controlled study
cyclic GMP
dimethyl sulfoxide
Drug discovery
formaldehyde
glutamic acid
Herbal
high performance liquid chromatography
hot plate test
jumping
licking
male
medicinal plant
Melastoma malabathricum
Melastoma malabathricum extract
Melastomaceae
methanol
methylene blue
morphine
mouse
n(g) nitroarginine methyl ester
naloxone
Natural products
nonhuman
opiate receptor
pain
Pain-killing
paw licking
plant extract
plant leaf
rat
toxicity testing
unclassified drug
vanilloid receptor
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