New class of acetylcholinesterase inhibitors from the stem bark of Knema laurina and their structural insights

New class of acetylcholinesterase inhibitors from the stem bark of Knema laurina and their structural insights

Bioassay-guided extraction of the stem bark of Knema laurina showed the acetylcholinesterase (AChE) inhibitory activity of DCM and hexane fractions. Further repeated column chromatography of hexane and DCM fractions resulted in the isolation and purification of five alkenyl phenol and salicylic acid...

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Bibliographic Details
Main Authors: Abas, F. (Author), Ahmad, S. (Author), Akhtar, M.N (Author), Atta-Ur-Rahman (Author), Choudhary, M.I (Author), Lajis, N.Hj (Author), Lam, K.W (Author), Maulidiani (Author), Shah, S.A.A (Author)
Format: Article
Language:English
Subjects:
2 hydroxy 6 (10' heptadecenyl)benzoic acid
2 hydroxy 6 (10' hydroxypentadec 8'enyl)benzoic acid
2 hydroxy 6 (pentadec 10' enyl)benzoic acid
3 heptadec 10' enylphenol
3 pentadec 10' enylphenol
Acetylcholinesterase inhibition
Alkyl resorcinol
article
bark
benzoic acid
Binding Sites
cholinesterase inhibitor
Cholinesterase Inhibitors
column chromatography
drug activity
drug isolation
drug purification
drug structure
hexane
hydrogen bond
hydrophobicity
IC 50
Inhibitory Concentration 50
Knema laurina
Knema laurina extract
Magnetic Resonance Spectroscopy
Models, Molecular
Molecular docking
molecular interaction
Molecular Structure
Myristicaceae
nuclear magnetic resonance spectroscopy
phenol derivative
plant extract
Plant Stems
salicylic acid
structure activity relation
unclassified drug
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