Inhibition of prostaglandin E2 production by synthetic minor prenylated chalcones and flavonoids: Synthesis, biological activity, crystal structure, and in silico evaluation

The discovery of potent inhibitors of prostaglandin E2 (PGE 2) synthesis in recent years has been proven to be an important game changer in pharmaceutical industry. It is known that excessive production of PGE2 triggers a vast array of biological signals and physiological events that contributes to...

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Bibliographic Details
Main Authors:	Abas, F. (Author), Abdul Bahari, M.N (Author), Ahmad, S. (Author), Ismail, N.H (Author), Jantan, I. (Author), Mohd Aluwi, M.F.F (Author), Rullah, K. (Author), Wai, L.K (Author), Wei, L.S (Author), Yamin, B.M (Author)
Format:	Article
Language:	English
Published:	Elsevier Ltd 2014
Subjects:	ADMET prediction alkylation animal animal cell Animals antagonists and inhibitors Article binding site Binding Sites biosynthesis carbon nuclear magnetic resonance cell death cell line Cell Line cell survival Cell Survival cell viability chalcone derivative Chalcones chemical structure chemistry chromatography computer model controlled study COX-2 inhibitor crystal structure cyclooxygenase 2 Cyclooxygenase 2 Dinoprostone dose response Dose-Response Relationship, Drug drug binding site drug cytotoxicity drug determination drug effects drug screening drug structure drug synthesis flavonoid Flavonoids human Humans hydrogen hydrogen bond IC50 Intramolecular Oxidoreductases isomerase lipopolysaccharide Lipopolysaccharides macrophage metabolism Mice Minor flavonoids Models, Molecular molecular docking Molecular Structure mouse MTT assay Murinae n (2 cyclohexyloxy 4 nitrophenyl)methanesulfonamide nonhuman Prenylated chalcone prostaglandin E synthase prostaglandin E2 prostaglandin inhibitor prostaglandin synthesis inhibition proton nuclear magnetic resonance Single-crystal XRD structure activity relation Structure-Activity Relationship Suzuki reaction synthesis X ray diffraction
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Inhibition of prostaglandin E2 production by synthetic minor prenylated chalcones and flavonoids: Synthesis, biological activity, crystal structure, and in silico evaluation

Internet

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