An activation to memory differentiation trajectory of tumor-infiltrating lymphocytes informs metastatic melanoma outcomes

An activation to memory differentiation trajectory of tumor-infiltrating lymphocytes informs metastatic melanoma outcomes

There is a need for better classification and understanding of tumor-infiltrating lymphocytes (TILs). Here, we applied advanced functional genomics to interrogate 9,000 human tumors and multiple single-cell sequencing sets using benchmarked T cell states, comprehensive T cell differentiation traject...

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Bibliographic Details
Main Authors: Anandasabapathy, N. (Author), Dannenfelser, R. (Author), Devi, K.S.P (Author), Elemento, O. (Author), Engelhard, V.H (Author), Garraway, L. (Author), Izar, B. (Author), Jaiswal, A. (Author), Kim, T.-G (Author), Melssen, M. (Author), Minkis, K. (Author), Nirschl, C.J (Author), Olson, W.C., Jr (Author), Regev, A. (Author), Slingluff, C.L., Jr (Author), Suárez-Fariñas, M. (Author), Tirosh, I. (Author), Troyanskaya, O. (Author), Verma, A. (Author), Yoon, C.H (Author)
Format: Article
Language:English
Published: Cell Press 2022
Subjects:
ICB
immune checkpoint blockade
immune persistence
melanoma
survival
systems biology
T cell memory
TILs
tumor-infiltrating lymphocytes
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