A TLR4-independent critical role for CD14 in intracellular LPS sensing

Intracellular lipopolysaccharide (LPS) sensing by the noncanonical inflammasome comprising caspase-4 or -11 governs antibacterial host defense. How LPS gains intracellular access in vivo is largely unknown. Here, we show that CD14-an LPS-binding protein with a well-documented role in TLR4 activation...

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Bibliographic Details
Main Authors: Kumari, P. (Author), Rathinam, V.A (Author), Russo, A.J (Author), Vanaja, S.K (Author), Vasudevan, S.O (Author)
Format: Article
Language:English
Published: NLM (Medline) 2022
Subjects:
LPS
Online Access:View Fulltext in Publisher