Dynamic spectrum of ectopic lymphoid B cell activation and hypermutation in the RA synovium characterized by NR4A nuclear receptor expression

Dynamic spectrum of ectopic lymphoid B cell activation and hypermutation in the RA synovium characterized by NR4A nuclear receptor expression

Ectopic lymphoid structures (ELS) can develop in rheumatoid arthritis (RA) synovial tissue, but the precise pathways of B cell activation and selection are not well understood. Here, we identify a synovial B cell population characterized by co-expression of a family of orphan nuclear receptors (NR4A...

Full description

Bibliographic Details
Main Authors: Accelerating Medicines Partnership Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA/SLE) Consortium (Author), Anolik, J.H (Author), Bombardieri, M. (Author), Corsiero, E. (Author), DiCarlo, E. (Author), Donlin, L.T (Author), Escalera-Rivera, K. (Author), Goodman, S. (Author), McDavid, A. (Author), Meednu, N. (Author), Orange, D.E (Author), Pitzalis, C. (Author), Prediletto, E. (Author), Rangel-Moreno, J. (Author), Raychauduri, S. (Author), Zhang, F. (Author)
Format: Article
Language:English
Published: NLM (Medline) 2022
Subjects:
B cells
CP: Immunology
ectopic lymphoid structure
rheumatoid arthritis
single-cell RNA-seq
synovial tissue
Online Access:View Fulltext in Publisher

Internet

View Fulltext in Publisher

Similar Items