Bacille Calmette-Guérin vaccine reprograms human neonatal lipid metabolism in vivo and in vitro

Bacille Calmette-Guérin vaccine reprograms human neonatal lipid metabolism in vivo and in vitro

Vaccines have generally been developed with limited insight into their molecular impact. While systems vaccinology enables characterization of mechanisms of action, these tools have yet to be applied to infants, who are at high risk of infection and receive the most vaccines. Bacille Calmette-Guéri...

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Bibliographic Details
Main Authors: Angelidou, A. (Author), Benn, C.S (Author), Conti, M.G (Author), Diray-Arce, J. (Author), EPIC Consortium (Author), Idoko, O. (Author), Jensen, K.J (Author), Kampmann, B. (Author), Kelly, R.S (Author), Kollmann, T.R (Author), Lasky-Su, J. (Author), Levy, O. (Author), Liu, M. (Author), McCulloch, S.D (Author), Michelloti, G. (Author), Ozonoff, A. (Author), Pettengill, M.A (Author), Steen, H. (Author), van Haren, S.D (Author)
Format: Article
Language:English
Published: NLM (Medline) 2022
Subjects:
BCG
CP: Immunology
innate immunity
lipidomics
lysophosphatidylcholine
metabolism
metabolomics
newborn
systems vaccinology
trained immunity
vaccine
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