Cholesterol determines the cytosolic entry and seeded aggregation of tau

Cholesterol determines the cytosolic entry and seeded aggregation of tau

Assemblies of tau can transit between neurons, seeding aggregation in a prion-like manner. To accomplish this, tau must cross cell-limiting membranes, a process that is poorly understood. Here, we establish assays for the study of tau entry into the cytosol as a phenomenon distinct from uptake, in r...

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Bibliographic Details
Main Authors: Cheng, S. (Author), James, L.C (Author), Katsinelos, T. (Author), Keeling, S. (Author), Knox, C. (Author), McEwan, W.A (Author), Metzakopian, E. (Author), Miller, L.V.C (Author), Smith, A.E (Author), Tredgett, L. (Author), Tuck, B.J (Author), Vaysburd, M.J (Author), Wilson, E.L (Author)
Format: Article
Language:English
Published: NLM (Medline) 2022
Subjects:
Alzheimer’s disease
cholesterol
CP: Metabolism
CP: Neuroscience
endocytosis
neurodegeneration
Niemann-Pick disease
seeded aggregation
tau
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