Basal cell carcinomas acquire secondary mutations to overcome dormancy and progress from microscopic to macroscopic disease

Basal cell carcinomas acquire secondary mutations to overcome dormancy and progress from microscopic to macroscopic disease

Basal cell carcinomas (BCCs) frequently possess immense mutational burdens; however, the functional significance of most of these mutations remains unclear. Here, we report that loss of Ptch1, the most common mutation that activates upstream Hedgehog (Hh) signaling, initiates the formation of nascen...

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Bibliographic Details
Main Authors: Dlugosz, A.A (Author), Doane, O.J (Author), Eberl, M. (Author), Ford, N.C (Author), Grachtchouk, M. (Author), Harms, P.W (Author), Ju, V. (Author), Peterson, J.K (Author), Swartling, F.J (Author), Trieu, K.G (Author), Tsai, S.-Y (Author), Veniaminova, N.A (Author), Wong, S.Y (Author)
Format: Article
Language:English
Published: NLM (Medline) 2022
Subjects:
basal cell carcinoma
CP: Cancer
Gli1
Gli2
hair follicle stem cells
N-myc
Notch
tumor dormancy
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