Aberrant H3K4me3 modification of epiblast genes of extraembryonic tissue causes placental defects and implantation failure in mouse IVF embryos

Aberrant H3K4me3 modification of epiblast genes of extraembryonic tissue causes placental defects and implantation failure in mouse IVF embryos

Assisted reproductive technology has been widely applied in the treatment of human infertility. However, accumulating evidence indicates that in vitro fertilization (IVF) is associated with a low pregnancy rate, placental defects, and metabolic diseases in offspring. Here, we find that IVF manipulat...

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Bibliographic Details
Main Authors: Bai, D. (Author), Chen, C. (Author), Chen, M. (Author), Gao, S. (Author), Han, X. (Author), Jia, Y. (Author), Jiang, C. (Author), Kou, X. (Author), Li, Y. (Author), Liu, K. (Author), Liu, W. (Author), Liu, Y. (Author), Ruan, J. (Author), Sun, J. (Author), Teng, X. (Author), Wang, H. (Author), Wang, Z. (Author), Yin, J. (Author), Zhang, Y. (Author), Zhao, Y. (Author)
Format: Article
Language:English
Published: NLM (Medline) 2022
Subjects:
CP: Developmental biology
CP: Molecular biology
extraembryonic tissue
H3K4me3
implantation
IVF
Kmt2e
placenta
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