Klebsiella pneumoniae induces host metabolic stress that promotes tolerance to pulmonary infection

Klebsiella pneumoniae induces host metabolic stress that promotes tolerance to pulmonary infection

K. pneumoniae sequence type 258 (Kp ST258) is a major cause of healthcare-associated pneumonia. However, it remains unclear how it causes protracted courses of infection in spite of its expression of immunostimulatory lipopolysaccharide, which should activate a brisk inflammatory response and bacter...

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Main Authors: Ahn, D. (Author), Annavajhala, M.K (Author), Beaumont, K.G (Author), Charytonowicz, D. (Author), Drikic, M. (Author), Ernst, R.K (Author), Fowler, B. (Author), Francoeur, N. (Author), Fucich, D. (Author), Gorrie, C.L (Author), Hachani, A. (Author), Hofstaedter, C.E (Author), Howden, B.P (Author), Khan, I.N (Author), Lewis, I.A (Author), McConville, T.H (Author), Mu, A. (Author), Oussenko, I. (Author), Prince, A. (Author), Sebra, R. (Author), Shah, S.S (Author), Shi, W. (Author), Smith, M.L (Author), Sridhar, S.H (Author), Stockwell, B.R (Author), Uhlemann, A.-C (Author), Upadhyay Baskota, S. (Author), Urso, A. (Author), Varisco, D. (Author), Wong Fok Lung, T. (Author)
Format: Article
Language:English
Published: Cell Press 2022
Subjects:
bacterial adaptation
disease tolerance
immunometabolism
immunosuppression
itaconate
Klebsiella pneumoniae
M2 macrophages
MDSCs
pulmonary infection
type 6 secretion system
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