Microscopy-based single-cell proteomic profiling reveals heterogeneity in DNA damage response dynamics

Microscopy-based single-cell proteomic profiling reveals heterogeneity in DNA damage response dynamics

Single-cell proteomics has the potential to decipher tumor heterogeneity, and a method like single-cell proteomics by mass spectrometry (SCoPE-MS) allows profiling several tens of single cells for >1,000 proteins per cell. This method, however, cannot link the proteome of individual cells with ph...

Full description

Bibliographic Details
Main Authors: Beerens, C. (Author), Bezstarosti, K. (Author), Chien, M.-P (Author), Demmers, J. (Author), Hsu, C.-C (Author), Kanaar, R. (Author), Pabst, M. (Author), Su, P.-R (Author), You, L. (Author)
Format: Article
Language:English
Published: Cell Press 2022
Subjects:
53BP1
DDR foci dynamics
DNA damage response
functional single-cell selection
PDS5A
phenotype-to-proteome linking
phototagging
single-cell proteomics
tumor heterogeneity
ultrawide field-of-view optical microscope
Online Access:View Fulltext in Publisher

Internet

View Fulltext in Publisher

Similar Items