BCL-3 loss sensitises colorectal cancer cells to DNA damage by targeting homologous recombination

BCL-3 loss sensitises colorectal cancer cells to DNA damage by targeting homologous recombination

The proto-oncogene BCL-3 is upregulated in a subset of colorectal cancers (CRC), where it has been shown to enhance tumour cell survival. However, although increased expression correlates with poor patient prognosis, the role of BCL-3 in determining therapeutic response remains largely unknown. In t...

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Bibliographic Details
Main Authors: Baird, D.M (Author), Chambers, A.C (Author), Collard, T.J (Author), Flanagan, D.J (Author), Ho, J.W.Y (Author), Morgan, R.G (Author), Ngo, G. (Author), Parker, C. (Author), Sansom, O.J (Author), Timms, P. (Author), Williams, A.C (Author)
Format: Article
Language:English
Published: Elsevier B.V. 2022
Subjects:
Colorectal cancer/DNA Damage response/Therapy response/Chemoradiotherapy/Homologous recombination
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