Multifunctional properties of Nej1XLF C-terminus promote end-joining and impact DNA double-strand break repair pathway choice

A DNA double strand break (DSB) is primarily repaired by one of two canonical pathways, non-homologous end-joining (NHEJ) and homologous recombination (HR). NHEJ requires no or minimal end processing for ligation, whereas HR requires 5’ end resection followed by a search for homology. The main event...

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Bibliographic Details
Main Authors: Adam, N. (Author), Cobb, J.A (Author), Mojumdar, A. (Author)
Format: Article
Language:English
Published: Elsevier B.V. 2022
Subjects:
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