Hypoxia-reprogrammed regulatory group 2 innate lymphoid cells promote immunosuppression in pancreatic cancer

Hypoxia-reprogrammed regulatory group 2 innate lymphoid cells promote immunosuppression in pancreatic cancer

Background: Previously, we uncovered a patient subgroup with highly malignant pancreatic cancer with serum markers CEA+/CA125+/CA19-9 ≥ 1000 U/mL (triple-positive, TP). However, the underlying immunosuppressive mechanism in the tumor immune microenvironment (TIME) of this subgroup is still unknown....

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Bibliographic Details
Main Authors: Gao, H. (Author), Han, X. (Author), Jin, K. (Author), Li, H. (Author), Li, T. (Author), Liao, Z. (Author), Lin, X. (Author), Liu, L. (Author), Wang, W. (Author), Wu, W. (Author), Xiao, Z. (Author), Xu, H. (Author), Ye, L. (Author), Yu, X. (Author), Zhang, W. (Author)
Format: Article
Language:English
Published: Elsevier B.V. 2022
Subjects:
Group 2 innate lymphoid cells (ILC2s)
Hypoxia
Pancreatic ductal adenocarcinoma (PDAC)
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