Using Mendelian randomisation to identify opportunities for type 2 diabetes prevention by repurposing medications used for lipid management

Using Mendelian randomisation to identify opportunities for type 2 diabetes prevention by repurposing medications used for lipid management

Background: Maintaining a healthy lifestyle to reduce type 2 diabetes (T2D) risk is challenging and additional strategies for T2D prevention are needed. We evaluated several lipid control medications as potential therapeutic options for T2D prevention using tissue-specific predicted gene expression...

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Bibliographic Details
Main Authors: Clarke, S.L (Author), Edwards, T.L (Author), Heberer, K.R (Author), Keaton, J.M (Author), Khankari, N.K (Author), Lee, K.M (Author), Lynch, J.A (Author), Miller, D.R (Author), Reaven, P.D (Author), Shuey, M.M (Author), Vujkovic, M. (Author), Walker, V.M (Author)
Format: Article
Language:English
Published: Elsevier B.V. 2022
Subjects:
Drug repurposing
Gene expression
Icosapent ethyl
Lipids
Mendelian randomisation
Statins
Type 2 diabetes
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