Mitochondrial interaction of fibrosis-protective 5-methoxy tryptophan enhances collagen uptake by macrophages

Mitochondrial interaction of fibrosis-protective 5-methoxy tryptophan enhances collagen uptake by macrophages

5-methoxy tryptophan (5-MTP) is an anti-fibrotic metabolite made by fibroblasts and epithelial cells, present in a micromolar concentrations in human blood, and is associated with the progression of fibrotic kidney disease, but the mechanism is unclear. Here, we show by microscopy and functional ass...

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Bibliographic Details
Main Authors: Chiara, J.L (Author), Chiara, M.-D (Author), El Aidy, S. (Author), Ioannidis, M. (Author), Jansma, J. (Author), Maassen, S. (Author), Maierhofer, L. (Author), Markus, H. (Author), van den Bogaart, G. (Author), Warner, H. (Author), Weavers, H. (Author)
Format: Article
Language:English
Published: Elsevier Inc. 2022
Subjects:
5-Methoxy tryptophan
Fibrosis
IDO
Inflammation
Macrophage
Metabolism
Mitochondria
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