pH triggered and charge attracted nanogel for simultaneous evaluation of penetration and toxicity against skin cancer: In-vitro and ex-vivo study

pH triggered and charge attracted nanogel for simultaneous evaluation of penetration and toxicity against skin cancer: In-vitro and ex-vivo study

The current research is focused to develop and investigate the toxicity and penetration potential of biocompatible chitosan nanogel encapsulating capecitabine by ionic interaction mechanism exhibiting pH triggered transdermal targeting. The nanogel (CPNL) was synthesized by ion gelation mechanism us...

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Bibliographic Details
Main Authors: Agrawal, R.K (Author), Iyer, A.K (Author), Jain, S. (Author), Kashaw, S.K (Author), Kushwah, V. (Author), Sahu, P. (Author), Sau, S. (Author)
Format: Article
Language:English
Published: Elsevier B.V. 2019
Subjects:
acidity
animal tissue
antineoplastic agent
Antineoplastic Agents
apoptosis
Apoptosis
Article
biocompatibility
capecitabine
Capecitabine
cell line
Cell Line
chemistry
chitosan
Chitosan
controlled study
diethylene glycol monoethyl ether
diffusion
Diffusion
drug carrier
Drug Carriers
drug cytotoxicity
drug diffusion
drug effect
Drug Liberation
drug penetration
drug release
drug retention
ethylene glycol derivative
Ethylene Glycols
ex vivo study
gel
gelation
Gels
HaCat cell line
human
human cell
Humans
Hydrogen-Ion Concentration
in vitro study
metabolism
nanoencapsulation
nanogel
Nanogel
nanomaterial
Nanostructures
nonhuman
particle size
Particle Size
permeability
Permeability
pH
pig
poloxamer
Poloxamer
skin
Skin
skin cancer
Skin cancer
Skin Neoplasms
skin penetration
skin tumor
steady state
Surface Properties
surface property
zeta potential
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