Diagnostic and therapeutic potential of shark variable new antigen receptor (VNAR) single domain antibody

Diagnostic and therapeutic potential of shark variable new antigen receptor (VNAR) single domain antibody

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Conventional monoclonal antibodies (mAbs) have been widely used in research and diagnostic applications due to their high affinity and specificity. However, multiple limitations, such as large size, complex structure and sensitivity to extreme ambient temperature potentially weaken the performance o...

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Bibliographic Details
Main Authors: Abdul Majeed, A.B (Author), Cheong, W.S (Author), Leow, C.H (Author), Leow, C.Y (Author)
Format: Article
Language:English
Published: Elsevier B.V., 2020
Subjects:
animal
Animals
Antibodies, Monoclonal
Antigen
antigen binding
Biomarker
complementarity determining region
epitope
fish protein
Fish Proteins
human
Immunodiagnostic
immunology
Immunotherapeutic
lymphocyte antigen receptor
molecular weight
monoclonal antibody
nanobody
nonhuman
protein expression
protein isolation
protein targeting
reagent
Receptors, Antigen
Review
serodiagnosis
shark
Sharks
single chain fragment variable antibody
Single domain antibody
Single-Chain Antibodies
somatic hypermutation
temperature sensitivity
thermostability
unclassified drug
variable new antigen receptor
Variable new antigen receptor (VNAR)
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