Diagnostic and therapeutic potential of shark variable new antigen receptor (VNAR) single domain antibody
Conventional monoclonal antibodies (mAbs) have been widely used in research and diagnostic applications due to their high affinity and specificity. However, multiple limitations, such as large size, complex structure and sensitivity to extreme ambient temperature potentially weaken the performance o...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier B.V.,
2020
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| Subjects: | |
| Online Access: | View Fulltext in Publisher View in Scopus |
| LEADER | 03081nam a2200625Ia 4500 | ||
|---|---|---|---|
| 001 | 10.1016-j.ijbiomac.2020.01.039 | ||
| 008 | 220121s2020 CNT 000 0 und d | ||
| 020 | |a 01418130 (ISSN) | ||
| 245 | 1 | 0 | |a Diagnostic and therapeutic potential of shark variable new antigen receptor (VNAR) single domain antibody |
| 260 | 0 | |b Elsevier B.V., |c 2020 | |
| 650 | 0 | 4 | |a animal |
| 650 | 0 | 4 | |a Animals |
| 650 | 0 | 4 | |a Antibodies, Monoclonal |
| 650 | 0 | 4 | |a Antigen |
| 650 | 0 | 4 | |a antigen binding |
| 650 | 0 | 4 | |a Biomarker |
| 650 | 0 | 4 | |a complementarity determining region |
| 650 | 0 | 4 | |a epitope |
| 650 | 0 | 4 | |a fish protein |
| 650 | 0 | 4 | |a Fish Proteins |
| 650 | 0 | 4 | |a human |
| 650 | 0 | 4 | |a Immunodiagnostic |
| 650 | 0 | 4 | |a immunology |
| 650 | 0 | 4 | |a Immunotherapeutic |
| 650 | 0 | 4 | |a lymphocyte antigen receptor |
| 650 | 0 | 4 | |a molecular weight |
| 650 | 0 | 4 | |a monoclonal antibody |
| 650 | 0 | 4 | |a nanobody |
| 650 | 0 | 4 | |a nonhuman |
| 650 | 0 | 4 | |a protein expression |
| 650 | 0 | 4 | |a protein isolation |
| 650 | 0 | 4 | |a protein targeting |
| 650 | 0 | 4 | |a reagent |
| 650 | 0 | 4 | |a Receptors, Antigen |
| 650 | 0 | 4 | |a Review |
| 650 | 0 | 4 | |a serodiagnosis |
| 650 | 0 | 4 | |a shark |
| 650 | 0 | 4 | |a Sharks |
| 650 | 0 | 4 | |a single chain fragment variable antibody |
| 650 | 0 | 4 | |a Single domain antibody |
| 650 | 0 | 4 | |a Single-Chain Antibodies |
| 650 | 0 | 4 | |a somatic hypermutation |
| 650 | 0 | 4 | |a temperature sensitivity |
| 650 | 0 | 4 | |a thermostability |
| 650 | 0 | 4 | |a unclassified drug |
| 650 | 0 | 4 | |a variable new antigen receptor |
| 650 | 0 | 4 | |a Variable new antigen receptor (VNAR) |
| 856 | |z View Fulltext in Publisher |u https://doi.org/10.1016/j.ijbiomac.2020.01.039 | ||
| 856 | |z View in Scopus |u https://www.scopus.com/inward/record.uri?eid=2-s2.0-85077739243&doi=10.1016%2fj.ijbiomac.2020.01.039&partnerID=40&md5=83a9d258abcb543741f4bd54a780e969 | ||
| 520 | 3 | |a Conventional monoclonal antibodies (mAbs) have been widely used in research and diagnostic applications due to their high affinity and specificity. However, multiple limitations, such as large size, complex structure and sensitivity to extreme ambient temperature potentially weaken the performance of mAbs in certain applications. To address this problem, the exploration of new antigen binders is extensively required in relation to improve the quality of current diagnostic platforms. In recent years, a new immunoglobulin-based protein, namely variable domain of new antigen receptor (VNAR) was discovered in sharks. Unlike conventional mAbs, several advantages of VNARs, include small size, better thermostability and peculiar paratope structure have attracted interest of researchers to further explore on it. This article aims to first present an overview of the shark VNARs and outline the characteristics as an outstanding new reagent for diagnostic and therapeutic applications. © 2020 Elsevier B.V. | |
| 700 | 1 | 0 | |a Abdul Majeed, A.B. |e author |
| 700 | 1 | 0 | |a Cheong, W.S. |e author |
| 700 | 1 | 0 | |a Leow, C.H. |e author |
| 700 | 1 | 0 | |a Leow, C.Y. |e author |
| 773 | |t International Journal of Biological Macromolecules |x 01418130 (ISSN) |g 147, 369-375 | ||