Rapid identification of isoprenylated flavonoids constituents with inhibitory activity on bacterial neuraminidase from root barks of paper mulberry (Broussonetia papyrifera)

This study was to assess the possibility of using competitive and slow binding experiments with affinity-based ultrafiltration UPLC-QTof-MS analysis to identify potent bacterial neuraminidase (bNA) inhibitors from the Broussonetia papyrifera roots extract. To isolate unbound compounds from the enzym...

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Bibliographic Details
Main Authors:	Jang, H.-J (Author), Jung, S. (Author), Kim, D.-Y (Author), Kim, W.J (Author), Lee, J. (Author), Lee, S.U (Author), Lim, G. (Author), Oh, S.-R (Author), Park, M.H (Author), Ryu, H.W (Author), Yuk, H.J (Author)
Format:	Article
Language:	English
Published:	Elsevier B.V. 2021
Subjects:	3' (3 methylbut 2 enyl) 3',4',7 trihydroxyflavane 3,4 dihydroxyisolonchocarpin 4 hydroxyisolonchocarpin 8 (1,1 dimethylallyl) 5' (3 methylbut 2 enyl) 3',4',5,7 tetrahydroxyflanvonol Affinity-based ultrafiltration antiinfective agent Article Bacterial neuraminidase docking bacteriostatic activity bark binding affinity broussochalcone A broussochalcone B broussoflavan A broussoflavonol B Broussonetia Broussonetia papyrifera Broussonetia papyrifera roots chalcone Chalcone chalcone derivative Chalcones chemistry controlled study drug effect drug identification drug isolation drug mechanism drug potency enzyme inhibition flavan derivative flavonoid Flavonoids flavonol derivative Flavonols IC50 isolation and purification isoprenylation kazinol A kazinol B kazinol B1 kazinol E kinetics Kinetics metabolism Neuraminidase nonhuman papyriflavonol A physiology Plant Bark plant extract Plant Extracts plant root Plant Roots polyphenol Polyphenols prenylation Prenylation quercetin sialidase time of flight mass spectrometry ultra performance liquid chromatography ultrafiltration unclassified drug
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Rapid identification of isoprenylated flavonoids constituents with inhibitory activity on bacterial neuraminidase from root barks of paper mulberry (Broussonetia papyrifera)

Internet

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