Influence of the disordered domain structure of MeCP2 on its structural stability and dsDNA interaction

Influence of the disordered domain structure of MeCP2 on its structural stability and dsDNA interaction

Methyl-CpG binding protein 2 (MeCP2) is a transcriptional regulator and a chromatin-associated structural protein. MeCP2 deregulation results in two neurodevelopmental disorders: MeCP2 dysfunction is associated with Rett syndrome, while excess of activity is associated with MeCP2 duplication syndrom...

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Bibliographic Details
Main Authors: Abian, O. (Author), Claveria-Gimeno, R. (Author), Esteller, M. (Author), Jorge-Torres, O.C (Author), Ortega-Alarcon, D. (Author), Vega, S. (Author), Velazquez-Campoy, A. (Author)
Format: Article
Language:English
Published: Elsevier B.V. 2021
Subjects:
amino terminal sequence
Article
binding site
biophysics
carboxy terminal sequence
chemistry
chromatin
Chromatin
controlled study
DNA
DNA binding protein
DNA methylation
DNA Methylation
DNA-Binding Proteins
human
Humans
intrinsically disordered protein
Intrinsically disordered protein (IDP)
metabolism
methyl CpG binding protein 2
Methyl-CpG-Binding Protein 2
Methyl-CpG-binding protein 2 (MeCP2)
mutation
Mutation
physiology
protein binding
Protein Binding
protein DNA interaction
protein domain
Protein Domains
protein function
protein secondary structure
protein stability
Protein Stability
Protein stability and interactions
protein structure
Protein Structure, Secondary
transcription factor
Transcription Factors
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