Epigallocatechin-3-gallate, an active ingredient of Traditional Chinese Medicines, inhibits the 3CLpro activity of SARS-CoV-2

SARS-CoV-2 is the etiological agent responsible for the ongoing pandemic of coronavirus disease 2019 (COVID-19). The main protease of SARS-CoV-2, 3CLpro, is an attractive target for antiviral inhibitors due to its indispensable role in viral replication and gene expression of viral proteins. The sea...

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Bibliographic Details
Main Authors:	Alsaadawe, M. (Author), Chen, X. (Author), Chen, Z. (Author), Disoma, C. (Author), Dong, Z. (Author), Du, A. (Author), Hu, L. (Author), Jiang, T. (Author), Li, S. (Author), Liu, P. (Author), Liu, S. (Author), Mo, L. (Author), Peng, J. (Author), Peng, Y. (Author), Razzaq, A. (Author), Shen, Y. (Author), Xia, Z. (Author), Yang, Q. (Author), Zhang, Q. (Author), Zhang, Y. (Author), Zheng, R. (Author), Zhou, Y. (Author)
Format:	Article
Language:	English
Published:	Elsevier B.V. 2021
Subjects:	3C-like proteinase, SARS-CoV-2 adult Adult age distribution antiviral activity Antiviral Agents antivirus agent Article artificial ventilation belamcanda catechin Catechin chaigechangyuan chaihuqingzao chemical composition chemistry China Chinese drug Chinese medicine clinical feature controlled study convalescent plasma therapy coronavirus 3C protease Coronavirus 3C Proteases coronavirus disease 2019 corticosteroid COVID-19 dayuanxiaodu drug effect drug protein binding drug screening drug therapy enzyme inhibition enzymology ephedre epidemiology epigallocatechin gallate Epigallocatechin-3-gallate female Female fluorescence resonance energy transfer Fluorescence Resonance Energy Transfer fuzhengjiedu human Humans IC50 immunoglobulin interferon lopinavir plus ritonavir maimendong san major clinical study male Male Medicine, Chinese Traditional metabolism middle aged Middle Aged molecular docking Molecular Docking Simulation moxifloxacin pandemic Pandemics procedures Protease Inhibitors proteinase inhibitor Retrospective Studies retrospective study sanren SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 sex difference shenlingbaizhu san surface plasmon resonance symptomatology thymosin alpha1 Traditional Chinese Medicine tramadol unclassified drug virology virus replication Virus Replication yangyinjiedu young adult Young Adult
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Epigallocatechin-3-gallate, an active ingredient of Traditional Chinese Medicines, inhibits the 3CLpro activity of SARS-CoV-2

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