A novel nuclear localization region in SIPA1 determines protein nuclear distribution and epirubicin-sensitivity of breast cancer cells

A novel nuclear localization region in SIPA1 determines protein nuclear distribution and epirubicin-sensitivity of breast cancer cells

Signal-induced proliferation-associated protein 1 (SIPA1) is highly expressed and mainly located in the nucleus in some breast cancer cell lines and clinical tumor tissues. Previous study revealed that nuclear localization of SIPA1 is functionally involved in breast cancer metastasis in the lymphati...

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Bibliographic Details
Main Authors: Ma, Y. (Author), Minato, N. (Author), Su, L. (Author), Wang, N. (Author), Weng, J. (Author), Zhang, Y. (Author)
Format: Article
Language:English
Published: Elsevier B.V. 2021
Subjects:
ABCB1
amino acid
amino acid sequence
Amino Acid Sequence
Amino Acids
Antibiotics, Antineoplastic
antineoplastic antibiotic
Article
Breast cancer
breast cancer cell line
Breast Neoplasms
breast tumor
cancer resistance
Cell Line, Tumor
cell migration
cell motion
Cell Movement
cell nucleus
Cell Nucleus
cell proliferation
Cell Proliferation
cell survival
Cell Survival
cellular distribution
chemistry
Chemotherapy
controlled study
drug effect
drug targeting
epirubicin
Epirubicin
fluorescence microscopy
genetics
GTPase-Activating Proteins
guanosine triphosphatase activating protein
HEK293 cell line
HEK293 Cells
histidine
human
human cell
Humans
MCF-7 cell line
MCF-7 Cells
metabolism
Microscopy, Fluorescence
multidrug resistance protein 1
mutation
Mutation
Nuclear localization
nuclear localization signal
Nuclear Localization Signals
nuclear protein
Nuclear Proteins
oncoprotein
pathology
protein expression
protein localization
SIPA1
SIPA1 protein
SIPA1 protein, human
tumor cell line
unclassified drug
upregulation
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