Molecular mechanism of anti-SARS-CoV2 activity of Ashwagandha-derived withanolides

Molecular mechanism of anti-SARS-CoV2 activity of Ashwagandha-derived withanolides

COVID-19 caused by SARS-CoV-2 corona virus has become a global pandemic. In the absence of drugs and vaccine, and premises of time, efforts and cost required for their development, natural resources such as herbs are anticipated to provide some help and may also offer a promising resource for drug d...

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Bibliographic Details
Main Authors: Agarwal, S. (Author), Dhanjal, J.K (Author), Garg, S. (Author), Kalra, R.S (Author), Kaul, A. (Author), Kaul, S.C (Author), Kumar, V. (Author), Subramani, C. (Author), Sundar, D. (Author), Vrati, S. (Author), Wadhwa, R. (Author), Wang, J. (Author), Zhang, H. (Author)
Format: Article
Language:English
Published: Elsevier B.V. 2021
Subjects:
A-549 cell line
A549 Cells
animal cell
antiviral activity
Antiviral Agents
antivirus agent
Article
binding affinity
cell line
Cell Line
cell survival
Cell Survival
cell viability
chemistry
clinical effectiveness
complex formation
computer simulation
Computer Simulation
controlled study
COVID-19
down regulation
Down-Regulation
drug effect
drug efficacy
drug mechanism
drug response
gene expression regulation
Gene Expression Regulation
HSC-3 cell line
human
Humans
in vitro study
Main protease (Mpro)
matrix protein
MCF-7 cell line
MCF-7 Cells
membrane protein, SARS-CoV-2
metabolism
Models, Molecular
molecular docking
molecular dynamics
Molecular Dynamics Simulation
molecular model
nonhuman
physiology
plant extract
Plant Extracts
protein conformation
Protein Conformation
protein expression
protein structure
SARS-CoV-2
Serine Endopeptidases
serine proteinase
Severe acute respiratory syndrome coronavirus 2
TMPRSS2 protein, human
transmembrane protease serine 2
Transmembrane protease serine 2 (TMPRSS2)
Viral Matrix Proteins
viral protein
virus entry
Virus Internalization
virus replication
Withania somnifera
withanolide
Withanolides
Withanosides
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