Determination of modification degree of polysialylated therapeutic proteins using 1H-NMR spectroscopy
Water soluble polymers and their derivatives bound to proteins can dramatically favor the biological activity of new drugs and vaccines. Quantification of the modification degree of the protein is crucial during the development and licensing phase and later in order to monitor the industrial product...
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Format: | Article |
Language: | English |
Published: |
Elsevier B.V.
2021
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Subjects: | |
Online Access: | View Fulltext in Publisher |