The method utilized to purify the SARS-CoV-2 N protein can affect its molecular properties

The method utilized to purify the SARS-CoV-2 N protein can affect its molecular properties

One of the main structural proteins of Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the nucleocapsid protein (N). The basic function of this protein is to bind genomic RNA and to form a protective nucleocapsid in the mature virion. The intrinsic ability of the N protein to interac...

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Bibliographic Details
Main Authors: Dobrucki, J. (Author), Greb-Markiewicz, B. (Author), Kolonko-Adamska, M. (Author), Ożyhar, A. (Author), Tarczewska, A. (Author), Zarębski, M. (Author)
Format: Article
Language:English
Published: Elsevier B.V. 2021
Subjects:
Article
chemistry
circular dichroism
controlled study
coronavirus nucleocapsid protein
Coronavirus Nucleocapsid Proteins
fluorescence recovery after photobleaching
Gel-like structures
hydrodynamics
intrinsically disordered protein
Intrinsically disordered protein (IDP)
Intrinsically Disordered Proteins
isolation and purification
liquid liquid extraction
Liquid-Liquid Extraction
Liquid-liquid phase separation (LLPS)
metabolism
nucleic acid
Nucleic Acids
oligomerization
phase separation
phase transition
procedures
protein aggregate
Protein Aggregates
protein aggregation
protein purification
protein quaternary structure
protein secondary structure
Protein Structure, Quaternary
Protein Structure, Secondary
SARS-CoV-2
structure analysis
ultracentrifugation
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