Mucosal IgA response elicited by intranasal immunization of Lactobacillus plantarum expressing surface-displayed RBD protein of SARS-CoV-2

Mucosal IgA response elicited by intranasal immunization of Lactobacillus plantarum expressing surface-displayed RBD protein of SARS-CoV-2

Coronavirus Disease 2019 (COVID-19) caused by a novel betacoronavirus SARS-CoV-2 has been an ongoing global pandemic. Several vaccines have been developed to control the COVID-19, but the potential effectiveness of the mucosal vaccine remains to be documented. In this study, we constructed a recombi...

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Bibliographic Details
Main Authors: Bai, J. (Author), Fu, T. (Author), Han, J. (Author), Hao, J. (Author), Jin, N. (Author), Li, C. (Author), Li, L. (Author), Tian, M. (Author), Wang, M. (Author), Zhu, G. (Author)
Format: Article
Language:English
Published: Elsevier B.V. 2021
Subjects:
Administration, Intranasal
animal
animal cell
animal experiment
animal tissue
Animals
Antibodies, Viral
Article
Bagg albino mouse
CD3+ T lymphocyte
CD4+ T lymphocyte
controlled study
coronavirus disease 2019
coronavirus spike glycoprotein
COVID-19
female
gene expression
Gene Expression
genetics
immune response
Immunity, Mucosal
immunization
immunoglobulin A
Immunoglobulin A
immunoglobulin A antibody
immunology
in vivo study
intestine tissue
intranasal drug administration
Intranasal immunization
Lactobacillus plantarum
Mice
Mice, Inbred BALB C
mouse
mucosal immunity
Mucosal vaccine
nonhuman
pandemic
prevention and control
protein analysis
protein domain
Protein Domains
protein expression
receptor binding
Receptor-binding domain (RBD)
recombinant protein
Recombinant Proteins
respiratory system
SARS-CoV-2
SARS-CoV-2 vaccine
Severe acute respiratory syndrome coronavirus 2
Spike Glycoprotein, Coronavirus
spike protein, SARS-CoV-2
spleen tissue
thermoregulation
virus antibody
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