Genomics-guided targeting of stress granule proteins G3BP1/2 to inhibit SARS-CoV-2 propagation

SARS-CoV-2 nucleocapsid (N) protein undergoes RNA-induced phase separation (LLPS) and sequesters the host key stress granule (SG) proteins, Ras-GTPase-activating protein SH3-domain-binding protein 1 and 2 (G3BP1 and G3BP2) to inhibit SG formation. This will allow viral packaging and propagation in h...

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Bibliographic Details
Main Authors:	AlAsmari, A.F (Author), Alharbi, M. (Author), Ali, N. (Author), Kumar, V. (Author), Prasad, K. (Author), Rashid, S. (Author)
Format:	Article
Language:	English
Published:	Elsevier B.V. 2021
Subjects:	Adaptor Proteins, Signal Transducing amino acid sequence animal cell apoptosis Article binding affinity binding protein bioinformatics chemistry Coronavirus Nucleocapsid Proteins COVID-19 dasatinib decitabine Decitabine DNA helicase DNA Helicases drug binding site drug delivery system Drug Delivery Systems drug therapy G3BP1 protein, human G3BP1/2 G3BP2 protein, human gene expression Gene set enrichment genomics Genomics hepatocyte nuclear factor 3alpha human human cell hypertension imatinib Imatinib Imatinib Mesylate metabolism molecular docking Molecular Docking Simulation molecular dynamics Molecular Dynamics Simulation mouse nonhuman nucleocapsid phosphoprotein, SARS-CoV-2 Nucleocapsid protein peripheral blood mononuclear cell phosphoprotein Phosphoproteins physiological stress poly ADP ribose binding protein Poly-ADP-Ribose Binding Proteins principal component analysis protein expression protein interaction protein kinase B protein kinase Syk protein structure Ras GTPase activating protein SH3 domain binding protein 2 Ras GTPase activating protein SH3 domain binding protein1 RNA binding protein RNA helicase RNA Helicases RNA recognition motif protein RNA Recognition Motif Proteins RNA-Binding Proteins SARS coronavirus SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 signal transducing adaptor protein signal transduction Stress granule transcription factor E2F1 transcription factor Sin3A transcription factor YY1 transforming growth factor beta receptor 2 unclassified drug Vero C1008 cell line Vero cell line virus replication
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Genomics-guided targeting of stress granule proteins G3BP1/2 to inhibit SARS-CoV-2 propagation

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