Silk sericin application increases bone morphogenic protein-2/4 expression via a toll-like receptor-mediated pathway

Silk sericin application increases bone morphogenic protein-2/4 expression via a toll-like receptor-mediated pathway

Bone morphogenic protein-2/4 (BMP-2/4) is an osteoinductive protein that accelerates osteogenesis when administered to bony defects. Sericin is produced by silkworms, and has a biological activity that differs depending on the degumming method used. Our results indicated that the high molecular weig...

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Bibliographic Details
Main Authors: Baek, K. (Author), Chae, W.-S (Author), Garagiola, U. (Author), Jo, Y.-Y (Author), Kang, Y.-J (Author), Kim, D.-W (Author), Kim, S.-G (Author), Kweon, H. (Author), Oh, J.-H (Author)
Format: Article
Language:English
Published: Elsevier B.V. 2021
Subjects:
animal
animal experiment
animal model
animal tissue
Animals
Article
beta sheet
biological model
Bombyx
Bombyx mori
bone morphogenetic protein 2
Bone Morphogenetic Protein 2
bone morphogenetic protein 4
Bone Morphogenetic Protein 4
Bone morphogenic protein
bone regeneration
Bone Regeneration
bone volume
chemistry
controlled study
denaturation
drug effect
gelatin
Gelatin
gelatin sponge
human
human cell
infrared spectroscopy
isolation and purification
metabolism
Mice
micro-computed tomography
molecular weight
Molecular Weight
monocyte
mouse
nonhuman
ossification
osteoblast
Osteoblasts
Osteogenesis
protein conformation
Protein Conformation
protein expression
protein secondary structure
Protein Structure, Secondary
rat
Rats, Sprague-Dawley
RAW 264.7 cell line
RAW 264.7 Cells
sericin
Sericins
signal transduction
Signal Transduction
silk
Silk
Silk sericin
Spectroscopy, Fourier Transform Infrared
Sprague Dawley rat
temperature
Temperature
TLR signaling
toll like receptor
toll like receptor 2
toll like receptor 3
toll like receptor 4
Toll-Like Receptors
ultrasound
X-Ray Microtomography
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