Spike protein recognizer receptor ACE2 targeted identification of potential natural antiviral drug candidates against SARS-CoV-2

Angiotensin-converting enzyme 2 (ACE2), also known as peptidyl-dipeptidase A, belongs to the dipeptidyl carboxydipeptidases family has emerged as a potential antiviral drug target against SARS-CoV-2. Most of the ACE2 inhibitors discovered till now are chemical synthesis; suffer from many limitations...

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Main Authors:	Abdullah-Al-Mamun, M. (Author), Ahammad, F. (Author), Alam, R. (Author), Bouback, T.A (Author), Hossen, M.S (Author), Imon, R.R (Author), Karpiński, T.M (Author), Nain, Z. (Author), Nur, S.M (Author), Pokhrel, S. (Author), Qadri, I. (Author), Rahman, M.S (Author), Samad, A. (Author), Talukder, M.E.K (Author), Tareq, M.M.I (Author)
Format:	Article
Language:	English
Published:	Elsevier B.V. 2021
Subjects:	ACE2 ACE2 protein, human amb 17613565 amb 21855906 amb 3940754 amb 6600091 angiotensin converting enzyme 2 Angiotensin-Converting Enzyme 2 animal experiment antiviral activity Antiviral Agents antivirus agent Article binding affinity binding site Binding Sites biological product Biological Products chemistry computer model computer simulation Computer Simulation controlled study coronavirus spike glycoprotein COVID-2019 dextro phenylalanine DOPA drug absorption drug binding site drug carcinogenicity drug cytotoxicity drug distribution drug effect Drug Evaluation, Preclinical drug excretion drug identification drug metabolism drug potency drug screening drug stability drug structure human Humans immunotoxicity LC50 LD50 levo saccharopine ligand Ligands lipophilicity liver toxicity metabolism mimosine MM/GBSA molecular docking Molecular docking Molecular Docking Simulation molecular dynamics Molecular dynamics simulation Molecular Dynamics Simulation nonhuman pharmacophore preclinical study procedures protein binding Protein Binding protein targeting rat SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Spike Glycoprotein, Coronavirus spike protein, SARS-CoV-2 structure activity relation Structure-Activity Relationship Structure-based pharmacophore model unclassified drug Virtual screening virus entry virus spike protein water solubility
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Spike protein recognizer receptor ACE2 targeted identification of potential natural antiviral drug candidates against SARS-CoV-2

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