Biochemical and structural studies of two tetrameric nucleoside 2′-deoxyribosyltransferases from psychrophilic and mesophilic bacteria: Insights into cold-adaptation

Nucleoside 2′-deoxyribosyltransferases (NDTs) catalyze the cleavage of glycosidic bonds of 2′-deoxynucleosides and the following transfer of the 2′-deoxyribose moiety to acceptor nucleobases. Here, we report the crystal structures and biochemical properties of the first tetrameric NDTs: the type I N...

Full description

Bibliographic Details
Main Authors:	Acebrón, I. (Author), Acosta, J. (Author), Alfaro, Y. (Author), Arroyo, M. (Author), De la Mata, I. (Author), Fernández-Lucas, J. (Author), Joachimiak, A. (Author), Kaminski, P.A (Author), Mancheño, J.M (Author), Nocek, B.P (Author), Wu, R.Y (Author)
Format:	Article
Language:	English
Published:	Elsevier B.V. 2021
Subjects:	2′-Deoxyribosyltransferases adaptation Adaptation, Physiological Article bacterial protein Bacterial Proteins Catalytic Domain cell level chemical phenomena Chemical Phenomena chemistry cold cold acclimatization Cold Temperature crystal structure Crystal structure disulfide Disulfides enzyme activation Enzyme Activation enzyme active site enzyme activity enzyme stability Enzyme Stability enzyme structure glycosyltransferase isolation and purification isoleucine leucine mesophilic bacterium Models, Molecular molecular model nonhuman nucleoside deoxyribosyltransferase Pentosyltransferases protein conformation Protein Conformation protein motif protein multimerization Protein Multimerization psychrophilic bacterium Psychrophilic enzymes recombinant protein Recombinant Proteins spectroscopy Spectrum Analysis structure analysis tetramer thermodynamics Thermodynamics transferase type I nucleoside 2' deoxyribosyltransferase type II nucleoside 2' deoxyribosyltransferase unclassified drug valine
Online Access:	View Fulltext in Publisher

Internet

View Fulltext in Publisher

Biochemical and structural studies of two tetrameric nucleoside 2′-deoxyribosyltransferases from psychrophilic and mesophilic bacteria: Insights into cold-adaptation

Internet

Similar Items