Structural and functional significance of the amino acid differences Val35Thr, Ser46Ala, Asn65Ser, and Ala94Ser in 3C-like proteinases from SARS-CoV-2 and SARS-CoV

Structural and functional significance of the amino acid differences Val35Thr, Ser46Ala, Asn65Ser, and Ala94Ser in 3C-like proteinases from SARS-CoV-2 and SARS-CoV

Three dimensional structures of (chymo)trypsin-like proteinase (3CLpro) from SARS-CoV-2 and SARS-CoV differ at 8 positions. We previously found that the Val86Leu, Lys88Arg, Phe134His, and Asn180Lys mutations in these enzymes can change the orientation of the N- and C-terminal domains of 3CLpro relat...

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Bibliographic Details
Main Authors: Denessiouk, K. (Author), Denesyuk, A.I (Author), Johnson, M.S (Author), Permyakov, E.A (Author), Permyakov, S.E (Author), Uversky, V.N (Author)
Format: Article
Language:English
Published: Elsevier B.V. 2021
Subjects:
(Chymo)trypsin-like proteinases
3C-like protease, SARS coronavirus
3C-like proteinase, SARS-CoV-2
amino acid substitution
Amino Acid Substitution
Autolysis
Catalytic tetrad
chemistry
Coronavirus 3C Proteases
COVID-19
enzymology
genetics
human
Humans
Interdomain loop
missense mutation
Mutation, Missense
protein domain
Protein Domains
SARS coronavirus
SARS Virus
SARS-CoV-2
species difference
Species Specificity
Structural catalytic core
structure activity relation
Structure-Activity Relationship
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