Structural and functional significance of the amino acid differences Val35Thr, Ser46Ala, Asn65Ser, and Ala94Ser in 3C-like proteinases from SARS-CoV-2 and SARS-CoV
Three dimensional structures of (chymo)trypsin-like proteinase (3CLpro) from SARS-CoV-2 and SARS-CoV differ at 8 positions. We previously found that the Val86Leu, Lys88Arg, Phe134His, and Asn180Lys mutations in these enzymes can change the orientation of the N- and C-terminal domains of 3CLpro relat...
Main Authors: | Denessiouk, K. (Author), Denesyuk, A.I (Author), Johnson, M.S (Author), Permyakov, E.A (Author), Permyakov, S.E (Author), Uversky, V.N (Author) |
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Format: | Article |
Language: | English |
Published: |
Elsevier B.V.
2021
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Subjects: | |
Online Access: | View Fulltext in Publisher |
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