Significant association of increased PD-L1 and PD-1 expression with nodal metastasis and a poor prognosis in oral squamous cell carcinoma

Significant association of increased PD-L1 and PD-1 expression with nodal metastasis and a poor prognosis in oral squamous cell carcinoma

Programmed cell death ligand 1 (PD-L1) and its receptor PD-1 are immune checkpoint molecules that attenuate the immune response. Blockade of PD-L1 enhances the immune response in a variety of tumours and thus serves as an effective anti-cancer treatment. However, the biological and prognostic roles...

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Bibliographic Details
Main Authors: Goto, Y. (Author), Hashiguchi, Y. (Author), Jinno, T. (Author), Kaneko, N. (Author), Kawano, S. (Author), Kitamura, R. (Author), Kiyoshima, T. (Author), Maruse, Y. (Author), Matsubara, R. (Author), Moriyama, M. (Author), Nakamura, S. (Author), Oobu, K. (Author), Sakamoto, T. (Author), Tanaka, H. (Author), Toyoshima, T. (Author)
Format: Article
Language:English
Published: Churchill Livingstone 2018
Subjects:
adult
Adult
aged
Aged
Aged, 80 and over
Article
B7-H1 Antigen
Biomarkers, Tumor
cancer cell
cancer grading
cancer growth
cancer prognosis
cancer staging
Carcinoma, Squamous Cell
cervical lymph node metastasis
correlation analysis
female
Female
human
human tissue
Humans
immune checkpoint
immune response
immunohistochemistry
Immunohistochemistry
inflammatory infiltrate
interleukin 2 receptor alpha
labeling index
lymph node metastasis
Lymphatic Metastasis
major clinical study
male
Male
metabolism
metastasis
middle aged
Middle Aged
Mouth Neoplasms
mouth squamous cell carcinoma
mouth tumor
Neoplasm Grading
Neoplasm Invasiveness
Neoplasm Staging
oral squamous cell carcinoma
pathology
prognosis
Prognosis
programmed cell death 1 (PD-1)
Programmed Cell Death 1 Receptor
programmed cell death ligand 1 (PD-L1)
programmed death 1 ligand 1
programmed death 1 receptor
protein expression
squamous cell carcinoma
T lymphocyte activation
tumor invasion
tumor marker
very elderly
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